Narayanan Parameswaran, BVSc., Ph.D.
Associate Professor of Physiology
Biomedical Physical Sciences Building
567 Wilson Rd Rm 3165
Department of Physiology
Michigan State University
East Lansing, MI 48824
Research focus of Parameswaran’s lab is directed towards understanding the cellular and biochemical mechanisms involved in the pathogenesis of inflammatory diseases. The emphasis is on two different protein families (arrestins and G-protein coupled receptor kinases, GRKs) in the context of how these proteins regulate signal transduction in innate immune cells (eg. macrophages) that is especially relevant in inflammation and disease. Arrestins are scaffolding proteins that can bind to receptors as well as signaling proteins and have a broad role in cell signaling. GRKs are serine/threonine kinases that can bind to and phosphorylate receptors and other intracellular substrates. Recent studies indicate that members of these two protein families have important functions in innate immune cells. Research in Parameswaran’s lab is currently focused towards understanding the biochemical and signaling mechanisms of arrestins and GRKs in immune cell types such as macrophages. How these functions of arrestins and GRKs are translated in disease pathogenesis is also another important area that is being pursued.
Beta-arrestin-1 deficiency protects mice from experimental colitis. Lee T, Lee E, Irwin R, Lucas PC, McCabe LR, Parameswaran N. Am J Pathol, 2013, In Press.
Colitis induced bone loss is gender dependent and associated with increased inflammation. Irwin R, Lee T, Young V, Parameswaran N, McCabe LR. Inflamm Bowel Dis, 2013, In Press.
G-protein coupled receptor kinase-5 mediates inflammation in a polymicrobial sepsis model in mice. Packiriswamy N, Lee T, Raghavendra PB, Durairaj H, Wang H, Parameswaran N. J Innate Immun, 2013, In Press.
Perspectives on some recent studies on RAMPs. Parameswaran N, Spielman WS. Adv Exp Med Biol. 2012; 744:105-12.
Regulation of GPCR trafficking by RAMPs. Bomberger JM, Parameswaran N, Spielman WS. Adv Exp Med Biol. 2012; 744:25-37.
Introduction to RAMPs. Parameswaran N, Spielman WS. Adv Exp Med Biol. 2012; 744:1-11.
Role of myeloid-specific G-protein coupled receptor kinase-2 in sepsis. Parvataneni S, Gonipeta B, Packiriswamy N, Lee T, Durairaj H, Parameswaran N. Int J Clin Exp Med. 2011; 4(4):320-30.
Free PMC Article
Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo. Packiriswamy N, Parvataneni S, Parameswaran N. Cell Immunol. 2012; 272(2):107-11.
Free PMC Article
G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice. Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N. J Cell Physiol. 2011 May; 226(5):1323-33.
Free PMC Article
Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice. Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N. J Cell Physiol. 2011 Mar; 226(3): 627-37. Free PMC Article
Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins. Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N. J Cell Physiol. 2010 Nov; 225(2): 406-16. Free PMC Article
Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Saini Y, Greenwood KK, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. Toxicol Sci. 2010 Aug; 116(2): 673-81. Free PMC Article
beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2. Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A.
Virus Res. 2010 Jan; 147(1): 123-34. Free PMC Article
G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα. Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N.
Biochem J. 2009 Dec 14; 425(1): 169-78. Free PMC Article
Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Shi Y, Porter K, Parameswaran N, Bae HK, Pestka JJ. Toxicol Sci. 2009 Jun; 109(2): 247-55. Free PMC Article
TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses. Appledorn DM, Patial S, Godbehere S, Parameswaran N, Amalfitano A. J Innate Immun. 2009; 1(4):376-88. Free PMC Article
Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A. J Immunol. 2008 Aug 1; 181(3):2134-44. Free Article
Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages. Loniewski K, Shi Y, Pestka J, Parameswaran N. Mol Immunol. 2008 Apr;45(8):2312-22.
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages. Loniewski KJ, Patial S, Parameswaran N.
Mol Immunol. 2007 Jul;44(15):3715-23.
RAMPs: The past, present and future. Parameswaran N, Spielman WS. Trends Biochem Sci. 2006 Nov;31(11):631-8.
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL. J Biol Chem. 2006 Nov 10;281(45):34159-70. Free Article
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