Skip to main content

Dr. Narayanan Parameswaran, Ph.D.

Associate Professor of Physiology

Dr. Nara Parameswaran, Ph.D.

Biomedical Physical Sciences Building
567 Wilson Rd Rm 3165
Department of Physiology
Michigan State University
East Lansing, MI 48824

(517) 884-5115

paramesw@msu.edu

 

Parameswaran lab

Research focus of Parameswaran’s lab is directed towards understanding the cellular and biochemical mechanisms involved in the pathogenesis of inflammatory diseases. The emphasis is on two different protein families (arrestins and G-protein coupled receptor kinases, GRKs) in the context of how these proteins regulate signal transduction in innate immune cells (eg. macrophages) that is especially relevant in inflammation and disease. Arrestins are scaffolding proteins that can bind to receptors as well as signaling proteins and have a broad role in cell signaling. GRKs are serine/threonine kinases that can bind to and phosphorylate receptors and other intracellular substrates. Recent studies indicate that members of these two protein families have important functions in innate immune cells. Research in Parameswaran’s lab is currently focused towards understanding the biochemical and signaling mechanisms of arrestins and GRKs in immune cell types such as macrophages. How these functions of arrestins and GRKs are translated in disease pathogenesis is also another important area that is being pursued.

Publications (last five years):
 Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins.

Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N.

J Cell Physiol. 2010 Nov; 225(2):406-16.

 G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.

Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N.

J Cell Physiol. 2010 Oct 13. [Epub ahead of print]

 Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.

Saini Y, Greenwood KK, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ.

Toxicol Sci. 2010 Aug;116(2):673-81.

 Myeloid-specific GPCR kinase-2 negatively regulates NFkappaB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn Ii GW, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2010 Aug 17. [Epub ahead of print]

beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.

Seregin SS, Appledorn DM, Patial S, Bujold M, Nance W, Godbehere S, Parameswaran N, Amalfitano A.

Virus Res. 2010 Jan;147(1):123-34.

G-protein-coupled-receptor kinases mediate TNFalpha-induced NF-kappaB signalling via direct interaction with and phosphorylation of IkappaBalpha.

Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N.

Biochem J. 2009 Dec 14; 425(1):169-78.

Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.

Shi Y, Porter K, Parameswaran N, Bae HK, Pestka JJ.

Toxicol Sci. 2009 Jun;109(2):247-55.

TRIF and TRIF-interacting TLRs differentially modulate several Ad vector-induced immune responses.

Appledorn DM, Patial S, Godbehere S, Parameswaran N, Amalfitano A.

J of Innate immunity, 2009, 1:376-388.

Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo.

Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N, Amalfitano A.

J Immunol. 2008 Aug 1;181(3):2134-44.

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.

Loniewski K, Shi Y, Pestka J, Parameswaran N.

Mol Immunol. 2008 Apr;45(8):2312-22.

Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

Loniewski KJ, Patial S, Parameswaran N.

Mol Immunol. 2007 Jul;44(15):3715-23.

RAMPs: The past, present and future.

Parameswaran N, Spielman WS.

Trends Biochem Sci. 2006 Nov;31(11):631-8. Review.

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.

Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL.

J Biol Chem. 2006 Nov 10;281(45):34159-70.

Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1.

Bomberger JM, Spielman WS, Hall CS, Weinman EJ, Parameswaran N.

J Biol Chem. 2005 Jun 24;280(25):23926-35.

Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.

Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS.

J Biol Chem. 2005 Mar 11;280(10):9297-307.  

Other Publications
This will open a new browser window and connect you in to the NIH Entrez search engine. Please, close the new window to come back to this page.


Max Docs: Pub. Date limit:

 

© 2011 Michigan State University Board of Trustees, East Lansing, MI 48824
MSU is an affirmative-action, equal-opportunity employer. Go State!