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Hongbing Wang, Ph.D.

Assistant Professor, Department of Physiology Neuroscience Program Cell and Molecular Biology Program Ph.D, UCLA

3179 BPS
Phone: 517-355-6475 Ext. 1138
E-mail: wangho@msu.edu

Areas of Research Interest

RESEARCH INTERESTS:
Neuroplasticity and long-term synaptic changes in the central nervous system are the results of neural activities. The activity-dependent changes take place at different levels. At the molecular level, post-translational modification, gene expression, and new protein synthesis are induced. At the cellular level, electrophysiological responses are potentiated; new synapses are generated; new neurons are born. These activity-dependent changes will ultimately modulate our mental function and behavior.
Our long-term goal is to understand how activity-stimulated cellular events lead to memory formation. We use multi-disciplinary approaches to understand the molecular mechanisms underlying neuroplasticity, such as in the cases of long-term potentiation and memory formation.

SELECTIVE PUBLICATIONS:

Wang, H, and Storm, D. (2005) Ca2+-stimulated Adenylyl Cyclases and Hippocampal Neuroplasticity. Cellscience. 2, 73-91.
Chen, X., Garelick, M., Wang, H., Athos, J., Li, V., and Storm, D. (2005) PI3 Kinase Signaling is Required for Retrieval and extinction of Contextual Memory. Nature Neuroscience. 8, 925-31.
Wang, H., Ferguson, G., Pineda, V, Cundiff, P., and Storm, D. (2004) Overexpression of Type 1 Adnenylyl Cyclase in Mouse Forebrain Enhances recognition Memory and LTP. Nature Neuroscience. 6, 635-42.
Pineda, V., Athos, J., Wang, H., Celver, J., Ippolito, D., Boulay, G., Birnbaumer, L., and Storm, D. (2004) Removal of Gi1 Constraints on Adenylyl Cyclase in the Hippocampus Enhances LTP and Impairs Memory Formation. Neuron. 41, 153-63.
Wang, H., Pineda, V., Chan, G., Wong, S., Muglia, L., and Storm, D. (2003) Type 8 Adenylyl Cyclase is Targeted to Excitatory Synapses and Required For Mossy Fiber Long-Term Potentiation. J. Neurosci. 23, 9710-18.
Wang, H., and Storm, D. (2003) Calmodulin-Regulated Adenylyl Cyclases: Cross-talk and Plasticity in the Central Nervous System. Mol Pharmacol. 63, 463-468.
Wang, H., Chan, G., Athos, J., and Storm, D. (2002) Synaptic Concentration of Type I Adenylyl Cyclase in cerebellar Neurons. J. Neurochem. 83, 946-54.
Wang, H., and Olsen, R.W. (2000) Binding of the GABAA Receptor-Associated Protein (GABARAP) to Microtubules and Microfilaments Suggests Involvement of the Cytoskeleton in GABARAP-GABAA Receptor Interaction. J. Neurochem. 75, 644-655.
Wang, H., Bedford, F., Brandon, N., Moss, S., and Olsen, R. (1999) GABAA-Receptor-Associated Protein Links GABAA Receptors and the Cytoskeleton. Nature, 397, 69-72.

Other Publications
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