Directory > Faculty
Elahé
Crockett, Ph.D.
Associate Professor of Physiology/Pathology
Pathophysiology of human disease processes: inflammation.
Areas
of Research Interest
INFLAMMATION is the area of research interest: Research projects
under study are:
1- Determining cellular and molecular mechanisms of inflammatory
tissue injury using both in vitro and in vivo model systems. The
role of adhesion molecules (selectins and ß2 integrins),
soluble mediators of inflammation (cytokines), and neutrophils
in inflammatory tissue injury is studied using murine models of
hepatic ischemia/reperfusion, and cecal ligation and puncture.
2- Examining regulation of inflammatory response by pro-inflammatory
and anti-inflammatory pathways such as the "cholinergic anti-inflammatory"
pathway. The role of nicotinic receptors is under current investigation.
We are interested in anti-inflammatory effect of nicotine and
acetylcholine.
3- Defining biochemical mechanisms of phagocytic cell (e.g. neutrophils)
activation through Fc and adhesion molecule receptors.
Methodology utilized in the laboratory includes; flow cytometry,
western, RT-PCR, microarray, ELISA, immunohistochemistry, and
light & electron microscopy.
Industrial Relevance:
1. Development of therapeutic means for the treatment of inflammatory
tissue injury associated with ischemia, trauma, and sepsis, in
human and animals.
Publications
1. Doeing DC, Borowicz JL, Crockett ET. Gender dimorphism in differential
peripheral blood leukocyte counts in mice using cardiac, tail,
foot, and saphenous vein puncture methods. BMC Clin Pathol. 2003,
3:3-8.
2. Lixin Li, Elahé Crockett, Donna H. Wang, James J. Galligan,
Gregory D. Fink, and Alex F. Chen. Gene transfer of eNOS and MnSOD
on arterial VCAM-1 expression and superoxide production in DOCA-salt
hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology,
2002, 22:249-255.
3. Mosher BD, RE Dean, J Harkema, D Remick, J Palma, and E. Crockett.
Inhibition of chemokines production by kupffer cells decreased
hepatic ischemia/reperfusion injury in mice. J. Surgical Research.
Aug. 2001, 99:201-210.
4. CS Young, J Harkema, RE Dean, D Naylor, E Crockett. Role of
P-selectin and Intercellular Adhesion Molecule-1 in Hepatic Ischemia/Reperfusion
Injury. Am Surgeons 2001, 67:737-744.
5. Crockett-Torabi E., and Fantone J.C. "Signal transduction
and adhesion molecules." pp 63-98, In: Adhesion Molecules
and the Lung. P A. Ward and J. C. Fantone (eds.). Marcel Dekker,
Inc. New York, NY. 1996.
Other Publications
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