Directory > Faculty
Nara Parmeswaran,
Ph.D.
 |
Associate Professor
of Physiology |
Cell signaling is a fundamental physiological process, aberrations
of which can lead to development of diseases. Cells are exposed
to a myriad of extracellular agents including hormones, and microorganisms
(eg. bacteria and viruses) to which the cells have developed sophisticated
mechanisms for receiving, processing and transmitting signals.
Broadly, our laboratory is interested in the areas of receptor
biology and signal transduction and how the various cellular events
are regulated in physiology as well as in pathology. Specifically,
our laboratory is currently focused on the regulation of G-protein
coupled receptor- (GPCR-), Toll-like receptor- (TLR-) and Tumor
necrosis factor receptor- (TNFR-) signaling in macrophages. Using
various approaches including RNAi and proteomics as well as cells-derived
from genetically modified mice, we are testing the regulation
of GPCR, TLR and TNFR signaling in the context of macrophage biology
such as cytokine secretion, gene expression, apoptosis, motility
and phagocytosis. Our current goals are to understand the role
of two major families of proteins namely arrestins (arrestin-2
and -3) and GPCR kinases (GRK-2, -3, -5, and -6) in GPCR-, TLR-
and TNFR-mediated signal transduction in macrophage biology.
PEER-REVIEWED PUBLICATIONS (SELECTED):
1. N. Parameswaran, C. Pao, K. Leonhard,
D.S. Kang, M. Kratz, S. Ley, and J.L. Benovic. ARRESTIN-2 AND
G-PROTEIN COUPLED RECEPTOR KINASE-5 INTERACT WITH NFkB1 p105 AND
NEGATIVELY REGULATE LIPOPOLYSACCHARIDE-STIMULATED ERK1/2 ACTIVATION
IN MACROPHAGES. In Press, 2006. Journal of Biological Chemistry.
ABSTRACT
2. N. Parameswaran and W. S. Spielman.
RAMPs: The past, present, and future. In Press, 2006. Trends in
Biochemical Sciences (TIBS). ABSTRACT
3. J.M. Bomberger, W.S. Spielman, C.S. Hall, E. Weinmann and N.
Parameswaran. RAMP ISOFORM-SPECIFIC REGULATION OF
ADRENOMEDULLIN RECEPTOR TRAFFICKING BY NHERF-1. 2005 June, (Epub
2005 April1), Journal of Biological Chemistry, 280(25): 23926-23935.
ABSTRACT
4. J.M. Bomberger, N. Parameswaran,
C.S. Hall, N. Aiyar, and W.S. Spielman. NOVEL FUNCTION FOR RECEPTOR
ACTIVITY MODIFYING PROTEINS (RAMPs) IN POST-ENDOCYTIC TRAFFICKING.
2005 Mar (Epub 2004 Dec 21,) Journal of Biological Chemistry,
280(10): 9297-307. ABSTRACT
5. N. Parameswaran, C.S. Hall, J. Bomberger,
and W.S. Spielman. REGULATION OF ADRENOMEDULLIN SIGNALING IN KIDNEY
INTERSTITIAL FIBROBLASTS. 2003, Cellular Physiology and Biochemistry,
13: 391-400. ABSTRACT
6. N. Parameswaran, C.S. Hall, J. Bomberger,
H.V. Sparks, D.B. Jump, and W.S. Spielman. NEGATIVE GROWTH EFFECTS
OF CIGLITAZONE ON KIDNEY MESANGIAL CELLS AND INTERSTITIAL FIBROBLASTS:
ROLE OF PPAR-y. 2003, Kidney and Blood Pressure research, 26(1),
2-9. ABSTRACT
7. N. Aiyar, J. Disa, Z. Ao, D. Xu, A. Surya, K. Pillarisetti,
N. Parameswaran, S. K. Gupta, S. A.
Douglas and P. Nambi. MOLECULAR CLONING AND PHARMACOLOGICAL CHARACTERIZATION
OF BOVINE CALCITONIN RECEPTOR −LIKE RECEPTOR FROM BOVINE AORTIC
ENDOTHELIAL CELLS. 2002, Biochemical Pharmacology, 63: 1949-1959.
ABSTRACT
8. V. Nowak, N. Parameswaran, C.S. Hall,
N. Aiyar, H.V. Sparks, and W.S. Spielman. A NOVEL REGULATION OF
ADRENOMEDULLIN RECEPTOR BY PDGF IN MESANGIAL CELLS- ROLE OF RECEPTOR
ACTIVITY MODIFYING PROTEIN-3. 2002. American Journal of Physiology-Cell
Physiology, 282: C1322-C1331. ABSTRACT
9. N. Parameswaran, C.S. Hall, B.C.
Bock, H.V. Sparks, K.A. Gallo, and W.S. Spielman. MIXED LINEAGE
KINASE 3 INHIBITS PLATELET-DERIVED GROWTH FACTOR-STIMULATED DNA
SYNTHESIS AND MATRIX MRNA EXPRESSION IN MESANGIAL CELLS. 2002,
Cellular Physiology and Biochemistry, 12 (5-6): 325-334. ABSTRACT
10. G.S. Filippatos, N. Gangopadhyay, O. Lalude, N.
Parameswaran, S.I. Said, W.S. Spielman, and B.D.
Uhal. REGULATION OF APOPTOSIS BY VASOACTIVE PEPTIDES. 2001, American
Journal of Physiology Lung cell Mol Physiol. 281: L749-L761. ABSTRACT
11. N. Parameswaran, W. Nowak, C.S.
Hall, H.V. Sparks, and W.S. Spielman. CELLULAR AND MOLECULAR MECHANISMS
OF ADRENOMEDULLIN ACTIONS IN MESANGIAL CELLS. 2001, Peptides,
22 (11): 1919-1924. ABSTRACT
12. N. Parameswaran, P. Nambi, J. Disa,
D. P. Brooks, W.S. Spielman, and N. Aiyar. ACTIVATION OF MULTIPLE
MITOGEN-ACTIVATED PROTEIN KINASES BY RECOMBINANT CALCITONIN GENE-RELATED
PEPTIDE RECEPTOR. 2000, European J of Pharmacology, 389(2-3):
125-130. ABSTRACT
13. Disa, J., N. Parameswaran, P. Nambi,
and N. Aiyar. INVOLVEMENT OF CAMP-DEPENDENT PROTEIN KINASE AND
PERTUSSIS TOXIN SENSITIVE G-PROTEIN IN CGRP-MEDIATED JNK ACTIVATION
IN HUMAN NEUROBLASTOMA CELLS. 2000, Neuropeptides, 34(3/4): 229-233.
ABSTRACT
14. N. Parameswaran, P. Nambi, H. Wu,
D. P. Brooks, N. Aiyar, and W.S. Spielman. REGULATION OF ADRENOMEDULLIN
RECEPTORS IN RAT MESANGIAL CELLS BY DESENSITIZATION AND RESENSITIZATION.
2000, European J of Pharmacology, 407(3): 205-210. ABSTRACT
15. W.S. Spielman, N. Parameswaran,
H.V. Sparks. ADENOSINE: AN INTRARENAL MEDIATOR OF RENAL FUNCTION.
In, The Kidney: Physiology and Pathophysiology, 3rd edition, 2000
(Editors: D.W. Seldin and G. Giebisch).
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