Directory > Faculty
Nara Parameswaran
, Ph.D.
 |
Assistant
Professor of Physiology
|
Broadly, our laboratory is interested in the areas of receptor
biology and signal transduction and how the various cellular events
are regulated in physiology as well as in pathology in a cell-type
specific manner. Specifically, our laboratory is currently focused
on the role of specific signaling pathways in monocytes and macrophages
with a particular reference to inflammatory diseases such as atherosclerosis
and arthritis. Aberrant activation of signaling pathways such
as mitogen-activated protein kinases (MAPK) and nuclear factor
kappa B (NFқB) pathways in macrophages are crucial in the development
of inflammatory diseases. Using various approaches including RNAi
and proteomics as well as genetically modified mice, we are testing
the regulation of signaling pathways in the context of macrophage
biology such as cytokine secretion, gene expression, apoptosis,
motility and phagocytosis. Our current goals are to understand
the role of two major families of proteins namely arrestins (arrestin-2
and -3) and GPCR kinases (GRK-2, -3, -5, and -6) in MAPK and NFқB
signaling pathways in macrophages in response to ligands for toll-like
receptors, tumor necrosis factor receptors and β-adrenergic receptors.
Selected Publications:
1. N. Parameswaran, C. Pao, K. Leonhard, D.S.
Kang, M. Kratz, S. Ley, and J.L. Benovic. ARRESTIN-2 AND G-PROTEIN
COUPLED RECEPTOR KINASE-5 INTERACT WITH NFB1 p105 AND NEGATIVELY
REGULATE LIPOPOLYSACCHARIDE-STIMULATED ERK1/2 ACTIVATION IN MACROPHAGES.
2006 Nov 10;281(45):34159-70 (Epub 2006 Sep 15)
Journal of Biological Chemistry.
2. N. Parameswaran and W. S. Spielman. RAMPs:
The past, present, and future. 2006 Nov;31(11):631-8 (Epub
2006 Sep 28) Trends in Biochemical Sciences (TIBS).
3. J.M. Bomberger, W.S. Spielman, C.S. Hall, E. Weinmann and
N. Parameswaran. RAMP ISOFORM-SPECIFIC REGULATION
OF ADRENOMEDULLIN RECEPTOR TRAFFICKING BY NHERF-1. 2005 June,
(Epub 2005 April1), Journal of Biological Chemistry,
280(25): 23926-23935.
4. J.M. Bomberger, N. Parameswaran, C.S. Hall,
N. Aiyar, and W.S. Spielman. NOVEL FUNCTION FOR RECEPTOR ACTIVITY
MODIFYING PROTEINS (RAMPs) IN POST-ENDOCYTIC TRAFFICKING. 2005
Mar (Epub 2004 Dec 21,) Journal of Biological Chemistry,
280(10): 9297-307. ABSTRACT
5. N. Parameswaran, C.S. Hall, J.
Bomberger, and W.S. Spielman. REGULATION OF ADRENOMEDULLIN SIGNALING
IN KIDNEY INTERSTITIAL FIBROBLASTS. 2003, Cellular
Physiology and Biochemistry, 13: 391-400. ABSTRACT
6. N. Parameswaran, C.S. Hall, J.
Bomberger, H.V. Sparks, D.B. Jump, and W.S. Spielman. NEGATIVE
GROWTH EFFECTS OF CIGLITAZONE ON KIDNEY MESANGIAL CELLS AND INTERSTITIAL
FIBROBLASTS: ROLE OF PPAR-y. 2003, Kidney
and Blood Pressure research, 26(1), 2-9. ABSTRACT
7. N. Aiyar, J. Disa, Z. Ao, D. Xu, A. Surya, K. Pillarisetti,
N. Parameswaran, S. K. Gupta, S. A.
Douglas and P. Nambi. MOLECULAR CLONING AND PHARMACOLOGICAL CHARACTERIZATION
OF BOVINE CALCITONIN RECEPTOR −LIKE RECEPTOR FROM BOVINE
AORTIC ENDOTHELIAL CELLS. 2002, Biochemical
Pharmacology, 63: 1949-1959. ABSTRACT
8. V. Nowak, N. Parameswaran, C.S.
Hall, N. Aiyar, H.V. Sparks, and W.S. Spielman. A NOVEL REGULATION
OF ADRENOMEDULLIN RECEPTOR BY PDGF IN MESANGIAL CELLS- ROLE OF
RECEPTOR ACTIVITY MODIFYING PROTEIN-3. 2002.
American Journal of Physiology-Cell Physiology, 282:
C1322-C1331. ABSTRACT
9. N. Parameswaran, C.S. Hall, B.C.
Bock, H.V. Sparks, K.A. Gallo, and W.S. Spielman. MIXED LINEAGE
KINASE 3 INHIBITS PLATELET-DERIVED GROWTH FACTOR-STIMULATED DNA
SYNTHESIS AND MATRIX MRNA EXPRESSION IN MESANGIAL CELLS. 2002,
Cellular Physiology and Biochemistry, 12 (5-6): 325-334.
ABSTRACT
10. G.S. Filippatos, N. Gangopadhyay, O. Lalude, N.
Parameswaran, S.I. Said, W.S. Spielman, and B.D.
Uhal. REGULATION OF APOPTOSIS BY VASOACTIVE PEPTIDES. 2001,
American Journal of Physiology Lung cell Mol Physiol.
281: L749-L761. ABSTRACT
11. N. Parameswaran, W. Nowak, C.S.
Hall, H.V. Sparks, and W.S. Spielman. CELLULAR AND MOLECULAR MECHANISMS
OF ADRENOMEDULLIN ACTIONS IN MESANGIAL CELLS. 2001,
Peptides, 22 (11): 1919-1924. ABSTRACT
12. N. Parameswaran, P. Nambi, J.
Disa, D. P. Brooks, W.S. Spielman, and N. Aiyar. ACTIVATION OF
MULTIPLE MITOGEN-ACTIVATED PROTEIN KINASES BY RECOMBINANT CALCITONIN
GENE-RELATED PEPTIDE RECEPTOR. 2000, European
J of Pharmacology, 389(2-3): 125-130. ABSTRACT
13. Disa, J., N. Parameswaran, P.
Nambi, and N. Aiyar. INVOLVEMENT OF CAMP-DEPENDENT PROTEIN KINASE
AND PERTUSSIS TOXIN SENSITIVE G-PROTEIN IN CGRP-MEDIATED JNK ACTIVATION
IN HUMAN NEUROBLASTOMA CELLS. 2000, Neuropeptides,
34(3/4): 229-233. ABSTRACT
14. N. Parameswaran, P. Nambi, H.
Wu, D. P. Brooks, N. Aiyar, and W.S. Spielman. REGULATION OF ADRENOMEDULLIN
RECEPTORS IN RAT MESANGIAL CELLS BY DESENSITIZATION AND RESENSITIZATION.
2000, European J of Pharmacology, 407(3):
205-210. ABSTRACT
15. W.S. Spielman, N. Parameswaran,
H.V. Sparks. ADENOSINE: AN INTRARENAL MEDIATOR OF RENAL FUNCTION.
In, The Kidney: Physiology and Pathophysiology, 3rd edition,
2000 (Editors: D.W. Seldin and G. Giebisch).
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